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Genetics From Genes to Genomes Study Set 1

Biology

Quiz 11 :

Analyzing Genomic Variation

Quiz 11 :

Analyzing Genomic Variation

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Allele-specific oligonucleotides (ASO)for the normal and disease alleles of a gene are in one section of a microarray.The disease is a recessive trait.If a probe made from an individual's genomic DNA hybridizes with both ASOs, what can be inferred about the individual?
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Answer:

C

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Simple sequence repeats are
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Answer:

B

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The most common mutant allele of the PAH gene, which is responsible for the metabolic disorder PKU, has a SNP in the splice donor site of one intron.What is the simplest way to detect this allele?
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Answer:

C

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Fragile X syndrome is caused by expansion of a trinucleotide repeat in the 5′ UTR of the FMR-1 gene.What is the simplest way to detect this expansion?
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Which is an example of a SNP? (Select all that apply. )
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Given that an individual is a compound heterozygote at the CFTR locus, the gene that causes cystic fibrosis, what can be inferred?
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Examine this pedigree that shows segregation of Huntington disease and the DNA marker G8.What was the most likely genotype of individual V-3 at the DNA marker? img
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What mechanisms contribute to the formation of deletions and insertions? (Select all that apply. )
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Which are limitations of preimplantation embryo diagnosis? (Select all that apply. )
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Which statement about SNPs in the human genome is true?
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Most polymorphisms do not result in a phenotypic difference because they are typically
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Positional cloning depends on knowing what?
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If a single DNA molecule is amplified by PCR, how many DNA molecules will exist after FIVE cycles?
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If the 13 CODIS SSR loci are genotyped, why does each person (except identical twins)have a unique combination of SSR alleles?
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How many bases do deletion-insertion polymorphisms (DIPs)most frequently involve?
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Simple sequence repeat loci are highly variable because of what process?
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Which is the most common type of DNA polymorphism?
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Which does a successful PCR require?
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Which are typically used for positional cloning of a disease gene in humans? (Select all that apply. )
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The classical form of the metabolic disease phenylketonuria is caused by a mutation in the gene encoding the enzyme phenylalanine hydroxylase (PAH), which converts phenylalanine to tyrosine.A variant form of phenylketonuria is caused by a mutation in a separate gene that encodes a different enzyme involved in the synthesis of a cofactor needed for PAH to function.Which of the following phenomena is illustrated by these two forms of phenylketonuria?
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