Genetics From Genes to Genomes Study Set 1

The enzymatic activity of CDKs is regulated by forming a complex with which proteins?

Which statement best describes the action of polypeptide growth factors?

The retinoblastoma (Rb)protein controls progression into S phase by regulating ________ activity.

The activity of Rb is controlled by

Which of the following is not likely to occur if p53 is inactivated?

A cellular process that results in cell death is

Which characteristic is typical of a cancer cell but not of a normal cell?

The enzyme telomerase is essential for unlimited cell division because

A karyotype of chromosomes from a cancer cell would be most likely to exhibit

The ability of a cell to move from the tissue to which it belongs to other parts of the body is known as

The current model of cancer development is that

In its active form, the Ras protein is associated with

What is one piece of evidence that supports the hypothesis that cancers are clonal?

What is the term for mutant alleles that can act dominantly to predispose a cell to a cancerous phenotype?

How can a mutation in a tumor-suppressor gene behave as a recessive allele at the cellular level, but appear as a dominant allele in pedigree analysis?

The human papillomavirus (HPV)carries a gene that functions as an oncogene by inactivating the p53 protein.The fact that the loss of p53 function is oncogenic suggests that

The BRCA2 protein functions in double-strand break repair.If a woman is heterozygous for a loss-of-function allele of BRCA2, she

What is the relationship between genomic instability and proliferation?

Drugs such as Gleevec^® and Herceptin^® represent a modern approach to cancer treatment because they

What is one reason why tumor-suppressor genes make poor druggable targets?