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Genetics From Genes to Genomes Study Set 1

Biology

Quiz 22 :

The Genetics of Complex Traits

Quiz 22 :

The Genetics of Complex Traits

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Complex quantitative traits often show
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C

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To test for statistical significance of the association of a SNP with a trait, the null hypothesis in a chi-square test for independence is that the one of the SNP alleles is more common in the Cases than in the Controls.
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False

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Typically, multiple interacting genes and the environment contribute to a complex quantitative trait, resulting in
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B

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The genetic relatedness of two siblings is
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In a GWAS experiment, 500,000 SNPs across the genome are genotyped in thousands of Case and Control individuals.Which statistical analysis should be applied and why?
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When the results of a GWAS experiment using 500,000 SNPs are plotted in a Manhattan plot, significantly associated SNPs are
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Most complex quantitative traits
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Introgressions are used to
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A SNP that can exist as a C or G is associated with a human disease.The genotypic odds ratio of the homozygote CC relative to the homozygote GG is 2.2, which indicates that
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In an experiment to distinguish genetic versus environmental effects on a trait, the test individuals
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Twins from two individual zygotes (dizygotic twins)
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The total phenotype variance (VP)is
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Which of the following is not true about monozygotic twins?
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During truncation selection, the realized heritability of a trait depends on the selection differential, which is the difference between the average trait value of the selected parents and the average trait value of the entire parental population.
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By definition, linkage disequilibrium means that
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Broad-sense heritability is defined as
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A SNP that can be either A or T is associated with a human disease.In the Case population, there were 2000 A alleles and 1500 T alleles.In the Control population, there were 2500 A alleles and 3000 T alleles.The allelic odds ratio indicates that the presence of an A confers a ________ times greater risk for the disease than does the T allele.
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A farmer performs truncation selection to try to increase the weight of peaches in his orchard.Which statement correctly describes a possible outcome of this selection?
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If a trait is heritable, then individuals with a genetic relatedness of 0.5 are expected to
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