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Human Pharmacology

Nursing

Quiz 3 :

Clinical Pharmacokinetics and Issues in Therapeutics

Quiz 3 :

Clinical Pharmacokinetics and Issues in Therapeutics

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For a 40-year-old, 75-kg man, drug X has a volume of distribution of 40 L and a clearance of 25 ml/min. Calculate the predicted loading dose of drug X to achieve a plasma concentration of 2 μg/ml.
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Multiple Choice
Answer:

Answer:

E
The loading dose is obtained by multiplying the goal plasma drug concentration by the volume of distribution.

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Which of the following is most likely increased in the average 70-year-old man compared with the average 30-year-old man?
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Multiple Choice
Answer:

Answer:

E
Of the options given, only α-1 acid glycoprotein plasma levels are increased in the elderly.

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Ketamine has a half-life of 2 ½ hours. If used as a continuous infusion at a dosage of 12.5 mg/hr for postoperative pain relief, how long will it take to achieve a practical steady-state concentration?
Free
Multiple Choice
Answer:

Answer:

D
The practical steady-state concentration is considered to occur after 5 half-lives. 5 times 2 ½ is 12 ½.