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Human Pharmacology

Nursing

Quiz 43 :

Insulin and Drugs Used in the Therapy of Diabetes Mellitus

Quiz 43 :

Insulin and Drugs Used in the Therapy of Diabetes Mellitus

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The sulfonylurea class of medications:
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Multiple Choice
Answer:

Answer:

A
All of the sulfonylureas promote insulin release by binding to the sulfonylurea subunit (SUR1) of the SUR1/Kir6.2 ATP-sensitive K+ channel. Binding inhibits channel conductance, resulting in partial depolarization of the membrane and activation of voltage-sensitive calcium channels. The resulting increase in cytosolic calcium promotes exocytosis of the secretory granules containing insulin.

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The incretins are a group of hormones that:
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Multiple Choice
Answer:

Answer:

C
Incretins stimulate the β cells to produce insulin and impair the ability of the α cells to secrete glucagon, particularly when circulating levels of glucose are high.