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Concepts of Genetics

Biology

Quiz 19 :

Cancer and Regulation of the Cell Cycle

Quiz 19 :

Cancer and Regulation of the Cell Cycle

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Describe the major cellular and molecular events that mark the entry of mitosis from G2.
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condensation of chromatin to form chromosomes, breakdown of the nuclear membrane, alterations in the cytoskeleton, formation of an active CDK1/cyclin B complex.

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What is the significance of CDK?
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CDK symbolizes a class of protein kinases, which, when activated, selectively phosphorylate target proteins. Many of these phosphorylated proteins are involved in cell-cycle control.

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Driver mutations provide a growth advantage to a tumor cell. Which type of mutation is known to accumulate in cancer cells but has no direct contribution to the cancer phenotype?
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B

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The retinoblastoma protein (pRB), like p53, serves as a(n) ________ in regulating the cell cycle.
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In sporadic cases of retinoblastoma, how many gene mutations are thought to be necessary in the same cell for a tumor to develop?
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What is the name of the protein that appears to regulate the entry of cells into an S phase? This protein is also known as the "guardian of the genome."
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Chronic myelogenous leukemia appears to be associated with a chromosomal rearrangement. How is a chromosomal rearrangement responsible for this disease?
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What functional differences exist between various cyclins?
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Which of the following general mechanisms appear to be involved in the formation of cancer cells?
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Mutant versions of genes that are normally involved in promoting the cell cycle are known as ________.
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Provide a definition of cancer at the anatomical level.
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Describe the general relationship that may exist between mutations and cancer.
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What is the name of the protein that combines with cyclins to exert local control of the cell cycle?
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Describe two classes of proteins known to be involved in the regulation of the cell cycle.
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Chronic myelogenous leukemia appears to be associated with a chromosomal rearrangement. Which chromosome(s) is(are) involved, and what is the name of the rearrangement?
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Name two of the classes of proteins that combine to directly control progression through the cell cycle.
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Which three stages or transitions in the cell cycle seem to serve as points of control (checkpoints)?
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Why do cancer researchers study molecular events associated with mitosis?
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Provide a definition of cancer at the genetic level.
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A protein functions as a cell-cycle regulator that causes cell death (apoptosis) to a damaged cell. What is the symbol given to this protein?
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