Quiz 16: Pharmacologic Management of Rheumatoid Arthritis and Osteoarthritis

By producing analgesic and anti-inflammatory effects,_____ is/are usually considered the first line of defense in treating rheumatoid arthritis. A)acetaminophen B)nonsteroidal anti-inflammatory drugs (NSAIDs) C)opioids D)leukotriene inhibitors E)anabolic steroids

NSAIDs are effective in treating rheumatoid arthritis because these drugs inhibit the _______ enzyme that initiates ______synthesis. A)cyclooxygenase;prostaglandin B)cyclooxygenase;steroid C)monoamine oxidase;dopamine D)monoamine;norepinephrine E)choline acetyltransferase;acetylcholine

Anti-inflammatory steroids (glucocorticoids)are often effective in controlling inflammation in rheumatoid arthritis,but prolonged use of large,systemic doses can cause: A)osteoporosis. B)muscle wasting. C)hypertension. D)diabetes mellitus. E)all of the above

Early and aggressive use of ______ can slow the progression of rheumatoid arthritis in many patients before there is extensive damage to affected joints. A)NSAIDs B)acetaminophen C)anabolic steroids D)disease-modifying antirheumatic drugs E)drugs that increase bone and cartilage destruction

All of the following drugs are considered "disease-modifying" antirheumatic drugs EXCEPT: A)NSAIDs such as aspirin. B)gold compounds such as auranofin (Ridaura). C)tumor necrosis factor-alpha inhibitors such as etanercept (Enbrel). D)antimalarials such as chloroquine (Aralen). E)methotrexate (Rheumatrex,others).

Because of its ability to decrease pain with minimal side effects such as gastric irritation,________ is often considered the drug of choice in mild-to-moderate osteoarthritis. A)aspirin B)acetaminophen C)prednisone D)cortisone E)methotrexate

In certain patients with osteoarthritis,viscosupplementation is preformed to restore the lubricating properties of synovial fluid by: A)administering oral anti-inflammatory steroids. B)administering oral NSAIDs. C)injecting anti-inflammatory steroids directly into the affected joint. D)injecting hyaluronan directly into the affected joint. E)injecting NSAIDs directly into the affected joint.

Because they may supply key ingredients needed for the production of articular cartilage and synovial fluid,some patients with osteoarthritis use dietary supplements such as _________. A)aspirin and acetaminophen B)prednisone and methylprednisone C)chloroquine and hydroxychloroquine D)ibuprofen and ketoprofen E)glucosamine and chondroitin