Quiz 36: Cancer Chemotherapy

Anticancer drugs are classified as cell-cycle-nonspecific if they exert antineoplastic effects on the cell only when it is in the _______ phase of the cell cycle. A)G1 B)G2 C)S D)M E)none of the above

Which of the following drug categories is not used to treat cancer? A)Alkylating agents B)Antimetabolites C)Interferons D)Drugs that increase mitosis E)Endocrines

Monoclonal antibodies may be especially effective in treating certain cancers because these drugs: A)create a strong alkyl reaction with the DNA molecule. B)directly inhibit the topoisomerase enzyme responsible for DNA synthesis. C)are attracted directly to the cancer cell without an appreciable affect on healthy tissues. D)directly inhibit the mitotic apparatus that is responsible for controlling cell division (mitosis) E)none of the above

A relatively new strategy for treating certain tumors is to prevent the formation of new blood vessels,thus impairing tumor growth by starving the tumor of oxygen and nutrients.Drugs that use this strategy are known as: A)topoisomerase inhibitors. B)angiogenesis inhibitors. C)aromatase inhibitors. D)antimetabolites. E)none of the above

Aspirin and similar nonsteroidal anti-inflammatory drugs (NSAIDs)may help prevent colorectal cancer and other malignancies by inhibiting the production of: A)new blood vessels. B)tumor necrosis factor alpha. C)interferons. D)interleukins. E)prostaglandins.

Most anticancer drugs exert severe and potentially toxic side effects because: A)these drugs have a high therapeutic index (TI). B)most of these drugs are not approved by the Food and Drug Administration (FDA). C)most of these drugs do not discriminate between healthy tissues and cancerous cells. D)these drugs all have extremely long half-lives,and tend to accumulate in the body for an extended period. E)the threshold dose of these drugs is typically much higher than in other drugs.