Quiz 37: Immunomodulating Agents

Drugs are used to suppress the immune system: A)to prevent rejection of transplanted organs or tissues. B)to limit immune-mediated damage to the body's tissues. C)to treat autoimmune diseases. D)all of the above E)none of the above

All of the following drugs can be used to suppress the immune system EXCEPT: A)azathioprine (Imuran). B)cyclophosphamide (Cytoxan,Neosar). C)cyclosporine (Neoral,Sandimmune). D)immunoglobulin G (Gamimune,other trade names). E)methotrexate (Folex,Rheumatrex).

Sirolimus (Rapamune),a relatively new immunosuppressant,is especially helpful following kidney transplants because: A)it causes sodium retention. B)it increases renin release from the kidneys. C)it does not reduce glomerular filtration and other aspects of kidney function. D)all of the above E)none of the above

Cyclosporine (Neoral),an immunosuppressant that is commonly used to prevent organ rejection,is often modified into microemulsion capsules so that: A)the drugs disperses more easily within the gastrointestinal tract. B)absorption of the drug from the gastrointestinal tract is more predictable. C)it is not as toxic to the kidneys and other tissues. D)all of the above E)none of the above

Cyclosporine (Neoral,Sandimmune)and tacrolimus (Prograf)suppress immune function by inhibiting the ______ protein in lymphoid tissues,which results in decreased production of _____. A)calcineurin;interleukin-2 B)interleukin-2;immunoglobulin G C)immunoglobulin G;prostaglandins D)prostaglandin;interleukin-2 E)interleukin-2;calcineurin

Glucocorticoids such as prednisone (Deltasone,other trade names)are often used to suppress immune function following organ transplant,but long-term use of these drugs can also cause: A)hypertension. B)increased chance of infection. C)adrenocortical suppression. D)breakdown of muscle,bone,skin,and various other tissues. E)all of the above