Genetics in Medicine

Medicine

Quiz 10 :

Identifying the Genetic Basis for Human Disease

Quiz 10 :

Identifying the Genetic Basis for Human Disease

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How are the linkage scores from multiple families combined?
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A

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What property is associated with the co-inheritance of marker alleles at frequencies that deviate from that expected based on the allele frequencies?
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B

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A false positive association that results from the use of a mixed population in an association study is caused by which of the following?
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B

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Using the following groups, compose a formula for the odds ratio for a disease-marker association. a. Affecteds who have marker allele of interest b. Affecteds who lack the marker allele of interest c. Controls who have the marker allele of interest d. Controls who lack the marker allele of interest
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Which of the following situations would support use of positional cloning for disease gene identification?
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Deviation from independent assortment of alleles is known as:
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Which of the following is a nonparametric linkage method?
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Which of the following is true ONLY for linkage analysis, as compared to association studies?
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What is the likely explanation for the smaller size of the linkage disequilibrium (LD) blocks in African populations compared to non-African populations?
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In this type of gene mapping, one looks for the inheritance of a particular segment of the genome in conjunction with the trait of interest.
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Which of the following does a logarithm of odds (LOD) score allow you to estimate?
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Which of the following is an assumption that must hold for large-scale association studies to be successful?
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Which of the following are possibly explanations for a positive result in an association study?
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Which of the following is true ONLY for association studies, as compared to linkage studies?
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What do tagSNPs define?
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