Genetics in Medicine

Medicine

Quiz 11 :

The Molecular Basis of Genetic Disease

Quiz 11 :

The Molecular Basis of Genetic Disease

Question Type
search
arrow
The hemoglobin E (HbE) allele of b globin, which is associated with reduced production of the b-globin chain, occurs at a very high frequency in which region?
Free
Multiple Choice
Answer:

Answer:

E

Tags
Choose question tag
close menu
arrow
Which of the following types of mutations can cause a loss of function to the protein?
Free
Multiple Choice
Answer:

Answer:

E

Tags
Choose question tag
close menu
arrow
Why can a-globin mutations have an effect earlier in life than b-globin mutations?
Free
Multiple Choice
Answer:

Answer:

B

Tags
Choose question tag
close menu
arrow
Which clinical phenotype is associated with an imbalance in the production of the a- and b-globin chains?
Multiple Choice
Answer:
Tags
Choose question tag
close menu
arrow
At which stage can a mutation disrupt the normal production of a protein?
Multiple Choice
Answer:
Tags
Choose question tag
close menu
arrow
Which of the following is the most common effect of a disease causing mutation on a protein?
Multiple Choice
Answer:
Tags
Choose question tag
close menu
arrow
Why is hydrops fetalis largely restricted to Southeast Asia?
Multiple Choice
Answer:
Tags
Choose question tag
close menu
arrow
Which clinical phenotype is associated with a b-chain mutation that locks the hemoglobin into the relaxed state, which has a high affinity for oxygen?
Multiple Choice
Answer:
Tags
Choose question tag
close menu
arrow
What is the effect of deletion of the locus control region for the b-globin gene cluster?
Multiple Choice
Answer:
Tags
Choose question tag
close menu
arrow
In addition to mutations in a globin, a thalassemia can result from mutations in which of the following genes?
Multiple Choice
Answer:
Tags
Choose question tag
close menu
arrow
Four sites associated with what type of DNA conformation are important for the regulatory control of b globin expression by the locus control region (LCR)?
Multiple Choice
Answer:
Tags
Choose question tag
close menu
arrow
A transition between which two hemoglobin molecules occurs around the time of birth?
Multiple Choice
Answer:
Tags
Choose question tag
close menu