Genetics in Medicine

Medicine

Quiz 15 :

Cancer Genetics and Genomics

Quiz 15 :

Cancer Genetics and Genomics

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What makes telomerase a viable target for cancer therapies?
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C

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Which of the following types of genes promotes cell proliferation and survival and, when mutated, can cause cancer?
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A

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Which of the following cancers have a genetic basis?
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E

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In addition to mutations in the coding region and regulatory elements, oncogenes often arise by which type of mutation?
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What is the likely mechanism by which chromosome 8;14 translocations cause Burkitt lymphoma?
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What pattern of inheritance does hereditary retinoblastoma exhibit at a phenotypic level?
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What chromosomal defect is found in the Philadelphia chromosome, which is associated with chronic myelogenous leukemia?
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Which of the following are types of tumor suppressors?
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How does the Philadelphia chromosome activate an oncogene?
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What function does a cancer stem cell serve in cancer development?
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In addition to loss of heterozygosity, the second hit in sporadic breast cancers with breast cancer gene 1 (BRCA1) or breast cancer gene 2 (BRCA2) mutations is often which of the following?
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Which of the following are used as criteria to decide whether genetic testing for hereditary nonpolyposis colon cancer (HNPCC) is appropriate?
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Which of the following can be cancer-associated genes by virtue of their ability to directly regulate the expression of protooncogenes and tumor suppressors, but which themselves are noncoding?
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In retinoblastoma, the "second-hit" mutation is:
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Mutations in what type of gene cause hereditary nonpolyposis colon cancer?
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Which of the following molecular phenotypes is associated with hereditary nonpolyposis colon cancer?
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Which of the following is more characteristic of hereditary retinoblastoma than sporadic retinoblastoma?
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What proportion of all cancers are hereditary cancer syndromes?
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Normally, the p53 protein responds to which of the following?
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Which type of mutation in MEN2 most commonly causes Hirschsprung disease and pheochromocytoma, respectively?
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