Genetics in Medicine

What makes telomerase a viable target for cancer therapies?

Which of the following types of genes promotes cell proliferation and survival and, when mutated, can cause cancer?

Which of the following cancers have a genetic basis?

In addition to mutations in the coding region and regulatory elements, oncogenes often arise by which type of mutation?

What is the likely mechanism by which chromosome 8;14 translocations cause Burkitt lymphoma?

What pattern of inheritance does hereditary retinoblastoma exhibit at a phenotypic level?

What chromosomal defect is found in the Philadelphia chromosome, which is associated with chronic myelogenous leukemia?

Which of the following are types of tumor suppressors?

How does the Philadelphia chromosome activate an oncogene?

What function does a cancer stem cell serve in cancer development?

In addition to loss of heterozygosity, the second hit in sporadic breast cancers with breast cancer gene 1 (BRCA1) or breast cancer gene 2 (BRCA2) mutations is often which of the following?

Which of the following are used as criteria to decide whether genetic testing for hereditary nonpolyposis colon cancer (HNPCC) is appropriate?

Which of the following can be cancer-associated genes by virtue of their ability to directly regulate the expression of protooncogenes and tumor suppressors, but which themselves are noncoding?

In retinoblastoma, the "second-hit" mutation is:

Mutations in what type of gene cause hereditary nonpolyposis colon cancer?

Which of the following molecular phenotypes is associated with hereditary nonpolyposis colon cancer?

Which of the following is more characteristic of hereditary retinoblastoma than sporadic retinoblastoma?

What proportion of all cancers are hereditary cancer syndromes?

Normally, the p53 protein responds to which of the following?

Which type of mutation in MEN2 most commonly causes Hirschsprung disease and pheochromocytoma, respectively?