Activation of zymogens is often accomplished by
A) aggregation of monomers to form the active oligomer.
B) post-synthetic modification.
C) formation of covalent crosslinks.
D) hydrolysis of specific peptide bonds.
E) addition of a cofactor.

Question

Quizplus · Accepted Answer

Activation of zymogens occurs by the hydrolysis of specific peptide bonds. This results in a conformational change that exposes the active site and allows the zymogen to become an active enzyme. An example is the activation of trypsinogen to trypsin by cleavage of a specific peptide bond.

Activation of Zymogens Is Often Accomplished by