Synthesis of insulin in the beta-cell involves several proteolytic cleavages post-translationally. The products of these enzymatic cleavages which are secreted normally are
A) proinsulin and insulin
B) insulin and C-peptide
C) insulin and insulin-like growth factor
D) proinsulin, insulin, insulin-like growth factor and relaxin
E) insulin

Question

Quizplus · Accepted Answer

The synthesis of insulin in the beta-cell involves the conversion of preproinsulin to proinsulin, which is then cleaved to form insulin and C-peptide. Therefore, the products of the enzymatic cleavages that are secreted normally are insulin and C-peptide.

Synthesis of Insulin in the Beta-Cell Involves Several Proteolytic Cleavages