The wobble hypothesis of base pairing
A) helps explain the specificity of amino acyl-tRNA synthetases.
B) helps to explain why a tRNA may carry several similar amino acids.
C) explains why fewer than 61 tRNAs are required to translate the 61 codons for amino acids.
D) accounts for the redundancy (or degeneracy) of the code.
E) helps explain the common sequence on the end of all tRNAs.

Question

Quizplus · Accepted Answer

The wobble hypothesis proposes that the first two bases of a codon pair strictly with the corresponding bases of the anticodon, but the third base can tolerate some degree of mismatch or modification. This allows for fewer than 61 tRNAs to be required to translate all 61 codons for amino acids because some tRNAs can bind to multiple codons through wobble base pairing.

The Wobble Hypothesis of Base Pairing