How is heparin induced thrombocytopenia (HIT)described?
A) It is an immunoglobulin G (IgG)immune-mediated adverse drug reaction that reduces circulating platelets.
B) It is a hematologic reaction to heparin in which the bone marrow is unable to produce sufficient platelets to meet the body's needs.
C) It is an immunoglobulin E (IgE)-mediated allergic drug reaction that reduces circulating platelets.
D) It is a cell-mediated drug reaction in which macrophages process the heparin and platelet complexes that are then destroyed by activated cytotoxic T cells.

Question

Quizplus · Accepted Answer

Heparin induced thrombocytopenia (HIT) is an immunoglobulin G (IgG) immune-mediated adverse drug reaction that reduces circulating platelets. This occurs due to the formation of IgG antibodies against heparin-PF4 (platelet factor 4) complexes, which activate platelets and cause a prothrombotic state. The reduction in circulating platelets can lead to an increased risk of thrombosis.

How Is Heparin Induced Thrombocytopenia (HIT)described