In disseminated intravascular coagulation (DIC),what activates the coagulation cascade?
A) Cytokines,such as platelet-activating factor (PAF),and tumor necrosis factor alpha (TNF-a)
B) Thromboxane A causing platelets to aggregate and consume clotting factors
C) Tissue factor (TF)located in the endothelial layer of blood vessels and subcutaneous tissue
D) Endotoxins from gram-negative and gram-positive bacteria circulating within the bloodstream

Question

Quizplus · Accepted Answer

Tissue factor (TF) located in the endothelial layer of blood vessels and subcutaneous tissue activates the coagulation cascade in DIC. TF is exposed in response to tissue damage or inflammation, leading to the formation of thrombin, which activates platelets and leads to the formation of fibrin clots. Other factors, such as cytokines and endotoxins, can also contribute to the activation of coagulation in DIC, but TF is considered the primary trigger. Thromboxane A2 is a product of activated platelets and contributes to platelet aggregation, but it is not the primary activator of coagulation in DIC.

In Disseminated Intravascular Coagulation (DIC),what Activates the Coagulation Cascade