Use the information below as background for the following questions.
Immunodeficiencies may be genetic in origin. Two examples of these are Bruton's agammaglobulinemia, an X-linked disorder, and DiGeorge syndrome, caused by a deletion from chromosome 22. Bruton's results in underdeveloped B cells, while DiGeorge syndrome results in a missing or seriously underdeveloped thymus.
-The DGS-like phenotype can be produced in a specific knockout mouse for HA3, a Hox gene. HA3 is known to be involved in developmental regulation in the mouse. Which of the following would be an appropriate test for following the gene in the mouse progeny?
A)bone marrow biopsy
B)assay for environmental agents known to cause birth defects
C)chest X-ray
D)measurement of the proportion of CD4 cells to total lymphocytes
E)autopsy examination of the thymus

Question

Quizplus · Accepted Answer

Measuring the proportion of CD4 cells to total lymphocytes would help assess thymus function, which is relevant for DiGeorge syndrome and the DGS-like phenotype in the knockout mouse.

Use the Information Below as Background for the Following Questions