Use the information below as background for the following questions.
Immunodeficiencies may be genetic in origin. Two examples of these are Bruton's agammaglobulinemia, an X-linked disorder, and DiGeorge syndrome, caused by a deletion from chromosome 22. Bruton's results in underdeveloped B cells, while DiGeorge syndrome results in a missing or seriously underdeveloped thymus.
-Which of the following might be a child with Bruton's disease?
A)baby girl Denise, with low level of antibody response to streptococcal infection
B)baby boy John, with immature T cells, missing CD4 receptors
C)baby boy Jeff, with no plasma cells following infection by bacterial pneumonia
D)baby girl Susan, with no evidence of a thymus gland
E)baby boy Matt, with very low circulating antigens

Question

Quizplus · Accepted Answer

Bruton's disease results in underdeveloped B cells, which are responsible for producing plasma cells that secrete antibodies against pathogens. As a result, individuals with Bruton's disease are unable to produce an antibody response to infections, which is reflected in the lack of plasma cells seen in baby boy Jeff after an infection with bacterial pneumonia.

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