Use the information below as background for the following questions.
Immunodeficiencies may be genetic in origin. Two examples of these are Bruton's agammaglobulinemia, an X-linked disorder, and DiGeorge syndrome, caused by a deletion from chromosome 22. Bruton's results in underdeveloped B cells, while DiGeorge syndrome results in a missing or seriously underdeveloped thymus.
-Bruton's disorder might occur because of which of the following molecular problems?
A)failure of heavy chain rearrangement in B cells
B)failure to incorporate CD4 receptors into cell membranes
C)underexpression of the gene for the beta chain of the T cell receptor
D)underexpression of the gene for the CD8 receptor molecule
E)inability of the bone marrow cells to interact with MHC molecules

Question

Quizplus · Accepted Answer

Bruton's agammaglobulinemia is caused by a failure of heavy chain rearrangement in B cells, which results in underdeveloped B cells and a deficiency in immunoglobulins.

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