You are studying adipocytes isolated via biopsy from a 12-year-old male patient who exhibits chronic hyperglycemia but with normal circulating levels of insulin. Your studies of these cells demonstrate that the density of insulin receptors is similar to adipocytes from control volunteers, binding kinetics are also identical, and the receptors become autophosphorylated in response to insulin binding. Given these observations it is most likely that there is a defect in which of the following insulin signal transduction proteins leading to the observed hyperglycemia in the subject? A) glycogen synthase kinase 3, GSK3 B) mammalian target of rapamycin, mTOR C) phosphodiesterase, PDE D) PIP₃-dependent protein kinase, PDK1 E) protein kinase B (PKB/Akt)

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The Answer of You are studying adipocytes isolated via biopsy from a 12-year-old male patient who exhibits chronic hyperglycemia but with normal circulating levels of insulin. Your studies of these cells demonstrate that the density of insulin receptors is similar to adipocytes from control volunteers, binding kinetics are also identical, and the receptors become autophosphorylated in response to insulin binding. Given these observations it is most likely that there is a defect in which of the following insulin signal transduction proteins leading to the observed hyperglycemia in the subject? A) glycogen synthase kinase 3, GSK3 B) mammalian target of rapamycin, mTOR C) phosphodiesterase, PDE D) PIP₃-dependent protein kinase, PDK1 E) protein kinase B (PKB/Akt)

You Are Studying Adipocytes Isolated Via Biopsy from a 12-Year-Old