Which of the following activities, relating to glucose homeostasis, is directly attributable to the actions of glucagon-like peptide-1 (GLP-1)?
A) decreased fatty acid release from adipose tissue
B) decreased glucagon release from the pancreas
C) increased transit of carbohydrates through the intestines
D) stimulated degradation of hepatic glycogen stores
E) unmasking of GLUT4 transporters in skeletal muscle

Question

Quizplus · Accepted Answer

GLP-1 is known to decrease glucagon release from the pancreas, which helps in maintaining glucose homeostasis by preventing excessive glucose production by the liver. The primary physiological responses to GLP-1 are glucose-dependent insulin secretion, inhibition of glucagon secretion, and inhibition of gastric acid secretion and gastric emptying. In addition, GLP-1 activity results in increased expression of the glucose transporter 2 (GLUT2) and glucokinase genes in pancreatic cells. The action of GLP-1 at the level of insulin and glucagon secretion results in significant reduction in circulating levels of glucose following nutrient intake.

Which of the Following Activities, Relating to Glucose Homeostasis, Is