Recent evidence has identified an enzyme involved in the modification of GLUT2 in pancreatic b-cells that is critically important for glucose-stimulated insulin secretion (GSIS). Which of the following represents this modification necessary for GLUT2 action?
A) acetylation
B) acylation
C) glycosylation
D) methylation
E) phosphorylation

Question

Quizplus · Accepted Answer

Glycosylation is a common post-translational modification that can affect protein function, including the activity of glucose transporters like GLUT2, which is crucial for glucose-stimulated insulin secretion in pancreatic beta cells.  The glycosyltransferase GnT-4a, encoded by the MGAT4A gene, is involved in generating the core GlcNAc linkage in N-glycosylated proteins. Nglycosylation of pancreatic GLUT2 is critical for its correct membrane localization, without which there can be no glucose uptake and thus, no GSIS

Recent Evidence Has Identified an Enzyme Involved in the Modification