As the level of adipose tissue increases there is a corresponding increase in inflammatory activities associated with this tissue. Which of the following factors is the most significant to the increased proinflammatory activities of expanding fat mass?
A) adiponectin
B) leptin
C) monocyte chemotactic protein-1, MCP-1
D) vascular cell adhesion molecule-1, VCAM-1
E) vascular endothelial cell growth factor, VEGF

Question

Quizplus · Accepted Answer

MCP-1 is a key chemokine that recruits monocytes to sites of inflammation, and its expression increases with expanding adipose tissue, contributing significantly to proinflammatory activities.  The significance of inflammatory responses elicited via secretion of adipose tissue- derived (WAT) cytokines relates to the fact that their production and secretion is increased in obese individuals. One key change in adipose tissue that results in increased synthesis and release of pro-inflammatory adipokines is an increase in the percentage of macrophages resident within the tissue. Macrophages are a primary source of pro-inflammatory cytokines secreted by adipose tissue. The primary adipokine responsible for this infiltration is monocyte chemotactic protein-1 (MCP-1).

As the Level of Adipose Tissue Increases There Is a Corresponding