You are comparing the responses of 2 strains of mice to the effects of a high-fat diet. Your observations show that one strain restricts their intake of food within a short period after accumulating a small gain in weight, whereas the other strain does not. The strain that does not limit their food intake quickly becomes obese. This latter strain of mice would most likely be shown to have a defect in the secretion of which of the following adipokines?
A) adiponectin
B) adipsin
C) leptin
D) resistin
E) vaspin

Question

Quizplus · Accepted Answer

Leptin is an adipokine involved in regulating energy balance by inhibiting hunger. A defect in leptin secretion or signaling can lead to uncontrolled food intake and obesity. Leptin is a peptide whose central function is the regulation of overall body weight by limiting food intake and increasing energy expenditure. Leptin exerts this effect within the brain via activation of the anorexigenic axis (appetite suppression) in the arcuate nucleus (ARC) of the hypothalamus

You Are Comparing the Responses of 2 Strains of Mice