Blocking the actions of which of the following hormones would be expected to lead to the greatest level of appetite suppression?
A) adiponectin
B) ghrelin
C) GLP-1
D) obestatin
E) peptide tyrosine tyrosine, PYY

Question

Quizplus · Accepted Answer

Ghrelin is known as the "hunger hormone" because it stimulates appetite. Blocking ghrelin would likely lead to significant appetite suppression. Ghrelin is produced and secreted by the X/A-like enteroendocrine cells of the stomach oxyntic (acid-secreting) glands. The major effect of ghrelin is exerted within the central nervous system at the level of the arcuate nucleus where it stimulates the release of neuropeptide Y (NPY) and agouti-related protein (AgRP). The actions of NPY and AgRP enhance appetite and thus, food intake.

Blocking the Actions of Which of the Following Hormones Would