Which of the following translation factors contains a modified amino acid recognized by a toxin produced by Diphtheria?
A) eIF-2B
B) eIF-4F
C) eEF-1α
D) eEF-2
E) eRF

Question

Quizplus · Accepted Answer

Diphtheria toxin targets eEF-2 by ADP-ribosylating a modified histidine residue called diphthamide, inhibiting protein synthesis.  A protein from Corynebacterium diphtheria which causes diphtheria catalyzes the ADPribosylation and inactivation of eEF-2. eEF-2 contains a modified His residue known as diphthamide and it is this residue that is the target of the toxin.

Which of the Following Translation Factors Contains a Modified Amino