Which of the following translation factors is the target of an interferon-mediated translational control mechanism?
A) eEF-1α
B) eEF-2
C) eIF-2
D) eIF-4A
E) eIF-4E

Question

Quizplus · Accepted Answer

Interferons can induce the phosphorylation of eIF-2, which inhibits its function and leads to a reduction in protein synthesis, as part of the antiviral response.  Regulation of translation in virally infected cells is accomplished by the induced synthesis of interferons (IFs). IFs are induced by dsRNAs and they induce a specific kinase termed RNA-dependent protein kinase (PKR) that phosphorylates the α-subunit of eIF-2, thereby shutting off translation in a similar manner to that of stress and heme control of translation.

Which of the Following Translation Factors Is the Target of an Interferon-Mediated