Chromatin remodeling is associated with alterations in the transcriptional activity of genes in the region of the remodeling. Which of the following statements is most correct concerning the events of chromatin remodeling?
A) chromatin remodeling occurs predominantly in regions enriched in CpG dinucleotides
B) histone acetylation tends to destabilize chromatin structure
C) methylation of guanine residues induces the remodeling event
D) methylation of histone H1 is sufficient to stimulate remodeling
E) remodeling is necessary to induce the property of genomic imprinting

Question

Quizplus · Accepted Answer

Histone acetylation reduces the positive charge on histones, decreasing their affinity for DNA and leading to a more open chromatin structure, which facilitates transcription.  The posttranslational modification of histone proteins has considerable effect on numerous activities at the level of the chromatin. In particular, the acetylation and/or methylation of histones in the nucleosome (H2A, H2B, H3, and H4) results in an altered stability of the 30-nm chromatin fiber as well as other higher-order chromatin structure. Imprinting is regulated by the state of DNA methylation.

Chromatin Remodeling Is Associated with Alterations in the Transcriptional Activity