Which of the following class of compounds is known to inhibit topisomerse II and thus have shown utility as cancer chemotherapeutics?
A) anthracyclins
B) antimetabolites
C) camptothecins
D) taxanes
E) vinca alkaloids

Question

Quizplus · Accepted Answer

Anthracyclines are known to inhibit topoisomerase II, which is crucial for DNA replication and repair, making them effective as cancer chemotherapeutics.  The anthracyclins were originally isolated from the fungus, Streptomyces. Doxorubicin (Adriamycin, Doxil, Rubex) and daunorubicin (Cerubidine, DaunoXome, Daunomycin, Rubidomycin) have similar modes of action, although doxorubicin is the more potent of the 2 and is used in the treatment of breast cancers, lymphomas, and sarcomas. The anthracyclins inhibit the actions of topoisomerase II.

Which of the Following Class of Compounds Is Known to Inhibit