Comparing the bacterial CRISPR system and the eukaryotic RNAi mediated by siRNAs, indicate whether each of the following CRISPR components is most analogous to Argonaute (A), siRNA (S), or target mRNA (T) in the RNAi pathway. Your answer would be a three-letter string composed of letter A, S, and T only.
( ) Cas
( ) Viral DNA
( ) crRNA

Question

Comparing the bacterial CRISPR system and the eukaryotic RNAi mediated by siRNAs, indicate whether each of the following CRISPR components is most analogous to Argonaute (A), siRNA (S), or target mRNA (T) in the RNAi pathway. Your answer would be a three-letter string composed of letter A, S, and T only.
( )	Cas
( )	Viral DNA
( )	crRNA

Quizplus · Accepted Answer

T
S
 Despite lacking homology, these two pathways share similarities: Cas can be guided by crRNAs to target invading viral DNA; similarly, an Argonaute or Piwi protein uses siRNAs to seek and cleave target mRNAs.

Comparing the Bacterial CRISPR System and the Eukaryotic RNAi Mediated