Some viruses encode a protease that cleaves the translation initiation factor eIF4G, rendering it unable to bind to eIF4E. What is the consequence of this cleavage?
A) It shuts down most of the cellular translation machinery, which causes the release of virus particles.
B) It favors viral protein synthesis because IRES-dependent translation initiation is inhibited.
C) It shuts down most host-cell protein synthesis and diverts the translation machinery to IRES-dependent initiation, thus favoring viral protein synthesis.
D) It favors viral protein synthesis by shutting down translation from uORFs.
E) It shuts down IRES-dependent translation, forcing the virus into latency.

Question

Quizplus · Accepted Answer

Translation of internal ribosome entry site (IRES)-containing mRNAs does not rely on the common cap-dependent initiation mechanism.

Some Viruses Encode a Protease That Cleaves the Translation Initiation