Quiz 20 :
Hemolytic Disease of the Fetus and Newborn

Which of the following best describes the principle of the Kleihauer-Betke test?

What tests are indicated for cord blood specimens if the mother has made anti-K?

Which severe outcome can be caused by indirect bilirubin levels greater than 18 mg/dL in the newborn?

All of the following are goals of an exchange transfusion except:

Why is suppression of erythropoiesis an advantage of exchange transfusions?

Why is reverse grouping omitted in neonate ABO grouping?

A cord blood specimen from a jaundiced infant should be tested for which of the following?

Why is the immediate spin eliminated in the prenatal antibody screen?

Which of the following reagents can be used to determine the immunoglobulin class of anti-M?

All of the following are characteristic of ABO hemolytic disease of the fetus and newborn (HDFN) except:

What is the physiological mechanism of Rh-immune globulin?

Which of the following treatments uses ultraviolet light to treat hyperbilirubinemia after the infant is delivered?

A 300-µg dose of Rh-immune globulin contains sufficient anti-D to protect against how much whole blood?

In HDFN, the IgG antibodies are directed against which antigen on the fetal red blood cells?

An O-positive mother gave birth to an A- negative baby. After 24 hours the newborn's bilirubin level rose to 18 mg/dL. A DAT performed on the cord blood specimen was positive with polyspecific AHG and anti-IgG reagents. It is probable that from maternal circulation is coating the newborn's red blood cells.

Which red blood cell morphology is most characteristic in ABO HDFN and absent in Rh HDFN?

How is an intrauterine transfusion performed?

Immunization of the mother can be caused by as little as D-positive fetal cells.

Active immunization induced by Rh(D) antigen can be prevented by the concurrent administration of:

Due to a short supply of O-negative packed cells, an Rh-negative patient was transfused with 1 unit of Rh-positive red blood cells. Calculate the number of Rh-immune globulin vials needed to protect against 250 mL of Rh-positive packed cells.

In order for the mother to be considered for Rh-immune globulin, her Rh type must be , and her newborn must be .

What is the most common clinical manifestation of ABO HDFN?

Which of the following red blood cells is appropriate for neonatal transfusions?

The laboratory is presented with a case of HDFN due to ABO incompatibility. The mother is Group O and the infant is Group B. The most appropriate type of blood to use for an exchange transfusion for this infant is:

The most important serologic test for the diagnosis of HDFN is the with anti-IgG reagents.

Which of the following antibodies have not been known to cause HDFN?

What is the physiological path of indirect bilirubin produced as a result of red blood cell destruction in HDFN?

All of the following are true regarding antibody titration of maternal IgG antibodies except:

The D-positive fetal cells in Rh-HDN are .

Why is the Rh-positive firstborn of an Rh-negative mother unaffected by Rh hemolytic disease of the fetus and newborn (Rh HDFN)?

Besides the Rh antibodies, what other red blood cell antibody is common to cause severe HDFN?

The results of a Kleihauer-Betke stain indicate a fetomaternal bleed of 40 ml of whole blood. How many vials of Rh-immune globulin would be required?

What effect does ABO incompatibility between mother and fetus have on maternal sensitization to Rh antigen?

Which of the following assays is used to calculate the amount of fetomaternal hemorrhage in a postpartum specimen?

In the event of a clinically significant antibody found in the mother's serum, which of the following must be performed to determine its concentration?

What is the cause of HDFN?

What immunoglobulin is capable of crossing the placenta?

What life-threatening disorder is characterized by a severe anemia, effusions, and ascites from hepatomegaly and splenomegaly?

What physiological phenomenon associates erythroblastosis fetalis with HDFN?

In which type of HDFN is the firstborn affected?

Cannulation of the umbilical vein under ultrasound guidance is known as:

Why are premature newborns more likely to require exchange transfusions than full-term infants?

Blood transfusions to the fetus and premature infants should be to prevent graft-versus-host disease.

Which IgG subclass carries more potency in red blood cell hemolysis?

When is the antenatal dose of Rh-immune globulin given?

Rh-immune globulin should be given within how many hours after delivery?

Which prenatal serologic tests are recommended during the first trimester?

Anti-D in the serum of a third trimester pregnant woman with a titer of 16 is indicative of:

How are units for exchange transfusion prepared?

Why does the rate of RBC destruction after birth decrease in an infant diagnosed with HDFN?

What is done to prevent HDFN caused by maternal anti-Jk^a antibody formation?

What is the role of the technologist in the diagnosis and clinical management of HDFN?

Rh-immune globulin is of no benefit after a person has been actively immunized and formed anti-D.

The antibody titer of maternal antibody is directly proportional to severity of HDFN.

All Rh-negative recipients who are transfused with as little as 1 mL of Rh-positive cells will develop anti-D.