Imagine you've isolated a yeast mutant that contains histones resistant to acetylation. What phenotype do you predict for this mutant?
A) The mutant will require galactose for growth.
B) The mutant will grow rapidly.
C) The mutant will show low levels of gene expression.
D) The mutant will show high levels of gene expression.

Question

Quizplus · Accepted Answer

Histone acetylation is one of the modifications that regulate gene expression by loosening the DNA-histone interaction, making it easier for the transcription machinery to access the DNA. A mutant with histones that are resistant to acetylation is likely to have less gene expression because the DNA-histone interaction will be tighter, making it harder for the transcription machinery to access the DNA. Therefore, the mutant will show low levels of gene expression.

Imagine You've Isolated a Yeast Mutant That Contains Histones Resistant