What is a key property of DNase that makes it useful for assessing whether chromatin is in a closed tightly condensed) or open loosely packed) configuration?
A) DNase cuts at specific DNA sequences.
B) DNase digests only mammalian DNA.
C) DNase preferentially digests DNA not associated with protein.
D) DNase is a protein.

Question

Quizplus · Accepted Answer

DNase preferentially cleaves DNA that is not associated with protein, meaning that regions of chromatin that are tightly condensed and associated with proteins will have less DNase accessibility, while regions of chromatin that are more open and less associated with proteins will have greater DNase accessibility.

What Is a Key Property of DNase That Makes It