How would the signal of a G protein-coupled receptor, without ligand, be affected if you made a G protein that converted GDP to GTP on its own without needing to be activated by the G protein-coupled receptor?
A)The signal wouldn't be affected; there is no ligand, thus no signal.
B)The signal wouldn't be affected; the ligand would be unable to bind due to the conformational change.
C)The G protein would be active but unable to signal due to the lack of ligand.
D)The G protein would be active and signaling, despite the lack of ligand.

Question

Quizplus · Accepted Answer

The G protein would be active and signaling, despite the lack of ligand, because it is constantly converting GDP to GTP on its own without needing to be activated by the G protein-coupled receptor. This can lead to abnormal signaling and cellular responses.

How Would the Signal of a G Protein-Coupled Receptor, Without