Adam, who has a cardiovascular disease, participated in a research study to identify genetic variations linked to cardiovascular disease. His DNA, along with DNA from other patients suffering from the same cardiovascular disease, was obtained. For the purpose of comparison, the researchers also took DNA samples from participants who did not have the disease. Each participant's DNA was assessed to determine markers of genetic variation. The researchers found that genetic variations occurred more frequently in people who had the cardiovascular disease. This led them to pinpoint the region in the human genome linked to the disease. Which of the following approaches to gene identification and discovery did the researchers use in this study?
A) next-generation sequencing
B) linkage analysis
C) the Thousand Genomes Project
D) the genome-wide association method

Question

Quizplus · Accepted Answer

The researchers used the genome-wide association method to identify genetic variations linked to cardiovascular disease. This approach compares the DNA of individuals with and without the disease to identify common genetic variations in the affected individuals. The study did not involve next-generation sequencing, which involves sequencing an individual's entire genome. The Thousand Genomes Project is a publicly funded project to sequence the DNA of a large number of individuals from across the world's population, but it was not used in this study. Linkage analysis is another genetic analysis method that tracks inheritance of a trait over multiple generations, which was not used in this study.

Adam, Who Has a Cardiovascular Disease, Participated in a Research