If you mutate the gene encoding a Cdk such that Cdk protein product cannot bind to cyclin, what effect would you expect to see?
A)Cdk will be unaffected.
B)The cell cycle will be up-regulated, and the cells will proliferate.
C)Cdk will be inactive, so the target proteins will not be phosphorylated.
D)Cdk will be constitutively active, so the cell cycle will be unchecked.
E)Cdk will phosphorylate its target proteins regardless of the cell cycle.
Mutations that inhibit Rb gene expression will have what effect on cell proliferation?
A)Cells will proliferate less, even if excess growth factors are present.
B)Cells will proliferate less because growth factors are absent.
C)Cells will proliferate more because growth factors are produced in excess.
D)Cells will proliferate more, regardless of growth factor concentration.
E)There will be no effect on cell proliferation; only apoptosis occurs.
During meiosis I, when does homologous chromosome pairing and recombination occur?
The binding of nonsister chromatids by a synaptonemal complex draws the homologs into close contact so that what process can occur?