A tumor suppressor gene undergoes a mutation that causes it to lose its normal function. What would be the most likely result of this mutation? A) The cell cycle halts and reverses back to the G₀ stage. B) The cell loses contact inhibition even when it is not surrounded by other cells. C) The cell cycle accelerates. D) The cell no longer responds to signals that cause it to stop dividing or undergo apoptosis. E) The cell stops dividing permanently and will never re-enter the cell cycle.

Question

Quizplus · Accepted Answer

Tumor suppressor gene products inhibit the cell cycle, so lifting the inhibition through loss of a tumor suppressor would render the cell unable to stop the cell cycle even when it is receiving signals to stop or to undergo apoptosis.

A Tumor Suppressor Gene Undergoes a Mutation That Causes It