Which observation suggested to Sutherland (1971 Nobel Prize winner) the involvement of a second messenger in adrenaline's effect on liver cells?
A) Receptor studies indicated that adrenaline was a ligand.
B) Glycogen breakdown was observed only when adrenaline was administered to intact cells.
C) Glycogen breakdown was observed when adrenaline and glycogen phosphorylase were combined in a cell-free system.
D) Adrenaline was known to have different effects on many types of cells.

Question

Quizplus · Accepted Answer

Glycogen breakdown was observed only when adrenaline was administered to intact cells, suggesting that an intracellular second messenger was involved in the signaling pathway.

Which Observation Suggested to Sutherland (1971 Nobel Prize Winner) the Involvement