How can the leading and lagging strands be synthesized in a coordinated fashion?
A) Specific enzymes control the size of the DNA opening.
B) Lagging-strand binding proteins inhibit leading-strand replication if the strands become disproportionate in size.
C) Polymerase III is a dimeric holoenzyme, and the looped lagging strand allows the enzyme to proceed in the same direction with each strand.
D) All of the above.
E) None of the above.

Question

Quizplus · Accepted Answer

Polymerase III is a dimeric holoenzyme that synthesizes both the leading and lagging strands. The looped lagging strand allows the polymerase to proceed in the same direction with each strand, ensuring that the leading and lagging strands are synthesized in a coordinated fashion. Specific enzymes, such as helicase and topoisomerase, are also involved in controlling the size of the DNA opening and preventing the strands from becoming disproportionate in size, but this does not directly address the coordination of leading and lagging strand synthesis.

How Can the Leading and Lagging Strands Be Synthesized in a Coordinated