The observed error rate in DNA replication is: A) 1 per 10⁶ nucleotides. B) 1 per 10⁴ nucleotides. C) 1 per 10⁸ nucleotides. D) 1 per 10¹⁵ nucleotides. E) None of the above.

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The observed error rate in DNA replication is approximately 1 per 10^8 nucleotides. This means that for every 100 million nucleotides copied, one error is made on average. Option A (1 per 10^6 nucleotides) and option B (1 per 10^4 nucleotides) are too frequent and option D (1 per 10^15 nucleotides) is too rare.

The Observed Error Rate in DNA Replication Is