The most common averse effects of anti-PD-1 and anti-CTLA-4 therapy for tumors is which of the following?
A)Infections
B)Autoimmune organ dysfunction
C)Hypoglycemia
D)Stroke
E)Asthma

Question

Quizplus · Accepted Answer

The targets of checkpoint blockade are required to maintain self-tolerance.Therefore,their use leads to excess activation of self-reactive T cells,as well as anti-tumor T cells.A wide range of autoimmune disorders is associated with these therapies,involving gut,lung,endocrine organs,and heart.Immunodeficiency leading to infections is not usually a complication.Diabetes with hyperglycemia (not hypoglycemia)due to autoimmune attack on pancreatic islets and loss of insulin production is observed in some patients receiving checkpoint blockers.Neither stroke nor asthma is associated with these therapies.

The Most Common Averse Effects of Anti-PD-1 and Anti-CTLA-4 Therapy