What change from normal is likely to result from the ingestion of ethanol?
A) increased reduction of pyruvate
B) increased conversion of beta-hydroxybutyrate to acetoacetate
C) decreased ketogenesis due to lack of acetyl-CoA
D) increased production of oxaloacetate from malate
E) increased production of dihydroxyacetone phosphate from glycerol phosphate

Question

Quizplus · Accepted Answer

Ethanol is metabolized by alcohol dehydrogenase to acetaldehyde, which is further metabolized to acetate by aldehyde dehydrogenase. The reduction of acetaldehyde to acetate requires NADH, leading to increased reduction of pyruvate to produce NADH.

Answer: C
 Ketogenesis requires acetyl-CoA, which is decreased due to ethanol metabolism. Ethanol metabolism leads to an increase in NADH, which inhibits the conversion of acetoacetate to beta-hydroxybutyrate, leading to increased levels of acetoacetate.

Answer: D and E are unlikely to result from the ingestion of ethanol.

What Change from Normal Is Likely to Result from the Ingestion