Free glycerol
A) is not a gluconeogenic substrate and is readily excreted in the urine.
B) is potentially gluconeogenic, and its point of entry into the gluconeogenic pathway is as pyruvate.
C) cannot support the net synthesis of glucose, because glycerol cannot be phosphorylated in vivo.
D) is potentially gluconeogenic, and its point of entry into the gluconeogenic pathway is as triose phosphate.
E) is ketogenic because it is derived from the catabolism of triacylglycerols.

Question

Quizplus · Accepted Answer

Free glycerol is potentially gluconeogenic, and its point of entry into the gluconeogenic pathway is as triose phosphate. Glycerol is converted to dihydroxyacetone phosphate by the enzyme glycerol kinase, allowing it to enter the gluconeogenic pathway as triose phosphate.

Free Glycerol