Why does the rapid reduction in ligand concentration play a role in terminating cell response in synaptic signaling, and not in endocrine signaling?
A) Antagonists are also present in the synapse
B) Hormones do not have degradative pathways
C) The receptors can be up-regulated in the synapse
D) The volume of the ligand environment is lower in the synapse
E) There is no regulation of hormone synthesis

Question

Quizplus · Accepted Answer

The synaptic gap is much smaller than the systemic circulation involved in endocrine signaling, allowing for rapid changes in ligand concentration to more directly and quickly affect cell response. In contrast, the larger volume involved in endocrine signaling means that changes in hormone concentration occur more slowly, making rapid reduction in ligand concentration less relevant for terminating cell response.

Why Does the Rapid Reduction in Ligand Concentration Play a Role