Certain bacterial exotoxins, such as cholera and pertussis, are useful in defining the steps and proteins in signal transduction pathways. Which of the following reactions best accounts for this toxin property? A) activation of specific lipid kinases B) covalent modification of heterotrimeric G proteins C) high?affinity binding to nuclear receptors D) inhibition of cyclic nucleotide hydrolysis E) rapid release of Ca²⁺ into cytosol

Question

Quizplus · Accepted Answer

Bacterial exotoxins such as cholera and pertussis covalently modify heterotrimeric G proteins, which are critical components of signal transduction pathways. This modification disrupts their normal function, leading to dysregulated signaling and cellular responses. By studying the effects of these toxins on G proteins, researchers can identify key steps and proteins involved in signal transduction pathways.

Certain Bacterial Exotoxins, Such as Cholera and Pertussis, Are Useful