All of the Following Effects May Occur in Enzyme Catalysis

All of the following effects may occur in enzyme catalysis EXCEPT which one?

A) Stabilization of transition states occurring between substrates and products.
B) General acid and base catalysis.
C) Lowering of the free energy of products, making a forward reaction thermodynamically more favorable.
D) Nucleophilic covalent catalysis, creating intermediates not possible in an uncatalyzed reaction.
E) Local concentration effects the orienting of substrate in configurations favorable to catalysis by reactive groups on an enzyme.