Which of the following statements about the interaction of heme units of hemoproteins with oxygen is correct?
A) Binding of 2,3-bisphosphoglycerate (BPG) to hemoglobin leads to increased binding of oxygen.
B) Binding of oxygen to one myoglobin increases the strength of binding of oxygen to other myoglobins.
C) In blood of peripheral tissues, the loss of an oxygen by a heme unit is balanced stoichiometrically by the loss of one hydrogen.
D) The binding of oxygen by separated beta-chains of hemoglobin is described by a sigmoid curve.
E) As oxygen binds to hemoglobin, the pKa's of certain amino acid sidechains decrease.

Question

Quizplus · Accepted Answer

The binding of oxygen to hemoglobin induces a conformational change that can affect the pKa of certain amino acid side chains, leading to the release of protons (H+). This is part of the Bohr effect, where the affinity of hemoglobin for oxygen decreases at lower pH, facilitating oxygen release in tissues where CO2 production and H+ concentration are high.

Which of the Following Statements About the Interaction of Heme