In the peptide below, what would be an initial product of the Edman reaction? ala-val-met-glu-ile-trp-ser-cys-glu
A) ala-val-met
B) Fluorescamine derivative of alanine
C) fluorescamine derivative of alanine
D) Phenylhydantoin derivative of alanine
E) valine

Question

Quizplus · Accepted Answer

The Edman reaction cleaves off the N-terminal amino acid of a peptide and converts it into a phenylthiohydantoin (PTH) derivative. Therefore, the initial product of the Edman reaction on the peptide ala-val-met-glu-ile-trp-ser-cys-glu would be the PTH derivative of alanine, which is option D.

In the Peptide Below, What Would Be an Initial Product